This study assesses the barriers and potentials for scaling MUS in Tanzania. It identifies pathways to overcome the water sector’s compartmentalization according to single water uses. Interviews with key stakeholders and literature review identified significant potentials for scaling MUS in Tanzania from five entry points. As MUS is about cross-sectoral dialogue and gradual change from many entry points that all contribute to an overall vision, it is proposed to implement these changes through a national MUS learning alliance of key stakeholders, including development partners.